630559, Koltsovo village, Novosibirsk region

tel: (3832) 36-60-10

fax: (3832) 36-74-09

e-mail:

http://www.vector.nsc.ru

State Scientific Center for Virology and Biotechnology "Vector" (SSC VB "Vector") is one of the largest research and production complexes in Russia. The main activities of the Center are conducting basic research in a wide area natural sciences and development and production of therapeutic, prophylactic and diagnostic drugs.

Fundamental research work of the Center is focused on obtaining new scientific knowledge in the field of molecular biology, virology, genetic engineering, biotechnology, epidemiology and ecology in order to use it in the interests of the national economy.

The history of the formation of the SSC VB "Vector" begins in 1974, when the head institute of the Center at that time, the All-Union Scientific Research Institute of Molecular Biology, was formed. In 1985, on its basis, the Scientific Research Institute was created Production Association"Vector", which received the status of a State Scientific Center in 1994.

Currently, the State Scientific Center for Virology and Biotechnology "Vector" unites a number of research institutes, production structures and other organizations. In addition, the Center is an associated member of a number of associations.

The main asset of the Center is a unique laboratory and experimental base, which has no analogues in Russia, which makes it possible to conduct research with viruses pathogenic for humans and animals in conditions of complete safety for personnel and environment. Highly qualified engineering, technical and scientific personnel have great experience work with especially dangerous viruses in the field of virology, molecular biology, genetic and cellular engineering, biotechnology, ecology and epidemiology.

As of April 1, 2000, the Center employs 1,842 employees, of whom 901 are engaged in scientific research, including 17 doctors and 147 candidates of science.

The training of highly qualified personnel is provided by the postgraduate school created at the Center in 1983, open in three specialties: molecular biology, virology and biotechnology. The SSC VB "Vector" has a dissertation council (D 208.020.01), in which 19 doctoral and 129 candidate dissertations were defended in the above specialties.

One of the Center’s tasks is to provide the Novosibirsk region with drugs from donor blood, including anti-tick immunoglobulin. In close contact with city clinics, work is underway to diagnose a number of infectious diseases (viral hepatitis A, B, C, D, AIDS, cytomegalovirus, herpes and toxoplasma infections) and to expand the scope of use of antiviral drugs developed at the State Research Center for Virus and Virology "Vector".

Over the past years, the Novosibirsk Administration has been funding a number of innovative projects State Research Center for Virology and Biochemistry "Vector", related to the development of immunobiological and medicinal products for medical purposes.

History of SSC VB "Vector"

1974 - Based on the Government Decree on the development of molecular biology and biotechnology, by order of the Main Directorate of Microbiological Industry under the Council of Ministers of the USSR (No. 1683 of 08/02/74), the All-Union Scientific Research Institute of Molecular Biology (VNII MB) was formed. The main task assigned to the Institute in those years was to study the fundamental features of the structure and function of especially dangerous viruses (VDV), experimentally study the pathogenesis of VDV, study the natural variability of specific viruses based on the analysis of the primary structure of their isolates obtained from different regions of the world, with the purpose of predicting the possibility of the emergence of new pathogens pathogenic for humans. In terms of application, the VNII MB was tasked with developing vaccine and diagnostic drugs using the latest achievements genetic engineering.

The All-Union Production Association "Biopreparat" made a decisive contribution to the creation and organization of the All-Union Research Institute of Medical Sciences. With the direct participation of professors V.I. Ogarkova, V.D. Belyaeva, Yu.T. Kalinina, A.A. Vorobyova, I.V. Nikonova, L.A. Klyucharev created the laboratory and experimental base of the All-Russian Scientific Research Institute of Medical Sciences.

The Siberian Branch of the USSR Academy of Sciences played an important role in the creation and development of the All-Russian Research Institute of Medical Sciences. Academicians M.A. took a great part in its organization. Lavrentiev, G.I. Marchuk, D.K. Belyaev, D.K. Knorre. VNII MB was provided with temporary space in Akademgorodok, where for the first 4 years it was carried out scientific work in close collaboration with the Novosibirsk Institute of Bioorganic Chemistry, Institute of Organic Chemistry, Institute of Cytology and Genetics. These are tight scientific connections have survived to this day.

1985 - The research and production association "Vector" (NPO "Vector") was created, which included VNII MB, NIKTI BAV (Research Design and Technological Institute of Biologically Active Substances), OPSP (Experimental Production Agricultural Enterprise) and NOPB (Scientific Experimental Industrial Base).

1994 - By Decree of the Government of the Russian Federation dated March 29, 1994 No. 247, NPO "Vector" was awarded the status of a state scientific center Russian Federation- State Research Center of Virology and Biotechnology "Vector". Order of the Ministry of Health and Medical Industry of the Russian Federation dated October 21, 1994 No. 210 approved the Charter of the state federal enterprise State Scientific Center for Virology and Biotechnology "Vector" of the Ministry of Health and Medical Industry of the Russian Federation.

1998 - Order of the Ministry of Health of the Russian Federation dated February 12, 1998 No. 40 approved changes and additions to the Charter of the State Unitary Enterprise State Scientific Center for Virology and Biotechnology "Vector" of the Ministry of Health of the Russian Federation.

1999 - Certificate of state accreditation from the Ministry of Science and Technology of the Russian Federation was received scientific organization State unitary enterprise State Scientific Center for Virology and Biotechnology "Vector" of the Ministry of Health of the Russian Federation dated April 22, 1999, No. 1091.

Currently, the State Scientific Center for Virology and Biotechnology "Vector" is a large research and production complex, including six research institutes, four subsidiaries, a branch (NIKTI BAV) and a number of other separate structural divisions.

Structure of SSC VB "Vector"

Research Institute of Molecular Biology

(Director - Corresponding Member of the Russian Academy of Sciences, Doctor of Biological Sciences, Professor S.V. Netesov)

• Fundamental and exploratory research in the field of classical and molecular virology, aimed at obtaining new scientific knowledge with the subsequent prospect of its use in the development of therapeutic, preventive and diagnostic drugs for the needs of healthcare and veterinary medicine.
• Study of the molecular diversity of human and animal viruses.
• Study of the evolution of the most dangerous viral pathogens of humans and animals, incl. at the molecular level, and development of methodology for monitoring viral diseases.
• Molecular epidemiological studies of transmission routes of viral infections.
• Applied research on the development of therapeutic, diagnostic and preventive drugs for medicine and veterinary medicine.
• Study of the mechanisms of functioning of genomes and proteins of pro- and eukaryotes.

Research Institute of Bioengineering

(Director - Doctor of Biological Sciences, Professor A.A. Ilyichev)

Main activities:

• Construction of heterologous gene expression systems in microbial cells to create on their basis producers of proteins of biomedical interest.
• Creation of protein variants with improved properties using protein engineering methods for their production and use in medical practice.
• Using phage display technology to map antigenic determinants of viral proteins, obtain functional mimetics of antigenic determinants, and construct recombinant antibodies against human and animal pathogens.
• Development of principles and methodological approaches designing vaccines against viral diseases.
• Development of diagnostic test systems, including those based on molecular hybridization and nucleic acid amplification for use in medicine and veterinary medicine.
• Study of structural and functional organizations viral genomes of farm animals.
• Study of the mechanisms of implementation of the biostimulating and repair effects of chitosan at the cellular level.
• Organization of production of chitogel preparations on the basis of the State Research Center for Virology and Biochemistry "Vector".
• Studying the interaction of recombinant filamentous phages with cell surface receptors with the aim of selecting recombinant variants that specifically interact with cancer cells.
• Using phage display technology to diagnose the early stages of atherosclerosis.
• Development of methods for rapid determination of M. tuberculosis resistance and investigation of the causes of its occurrence.
• Study by molecular biological methods of M. tuberculosis isolates circulating in the West Siberian region and creation of their representative collection.
• Study of factors influencing the effectiveness of tuberculosis immunoprophylaxis and determination possible ways improving the vaccine.

Research Institute "Collection of Cultures and Microorganisms"

(Director - Candidate of Biological Sciences V.E. Repin)

Main activities:

• Isolation, typing and storage of viral and bacterial strains, strains of producers of biologically active substances, genetically marked strains and genetic constructs obtained in domestic and foreign laboratories.
• Studying the properties of newly obtained strains, including genetically modified variants of previously known strains; their certification, including using the method of genomic fingerprinting; deposit and storage.
• Obtaining strains of microorganisms for use in environmental interests.
• Development of technology for the production of viral, bacterial and fungal entomopathogenic drugs.
• Maintaining and studying the national collection of variola virus strains.

Research Institute of Cell Cultures

(Director - Candidate of Medical Sciences E.A. Nechaeva)

Main activities:

• Replenishment and maintenance of a bank of cell cultures of vertebrates, insects and plants, certification of lines and strains.
• Obtaining and certification of new lines and productive clones.
• Receipt and storage of seed and working banks of cell cultures producing biologically active substances, their certification in accordance with WHO requirements.
• Providing pilot industrial developments, research and experimental work at the State Research Center for Virology and Biochemistry "Vector" with continuous and primary cell cultures.
• Development and implementation of new production technologies medicines using cell engineering technology.
• Development, improvement and implementation of new technologies for the preparation of vaccine preparations using cell cultures and ways of delivering the vaccine to a living organism; development of new forms of their application.
• Development of technology for obtaining human cells for skin restoration.
• Development of technology for the production of hyaluronic acid.
• Production of live measles vaccine.
• Production of nutrient media for the cultivation of cells and viruses.
• Production of "Gemovect" solutions for use in hemodialysis and "Transvect" for storing transplants.
• Large blood serum production cattle and horses.

Research Institute of Aerobiology

(Director - Candidate of Technical Sciences V.S. Toporkov)

The main activities of the Institute are related to fundamental and applied research in the field of ecology, medicine and healthcare. The Institute conducts bioaerosol research in the interests of medicine, virology and ecology. Development is also underway modern technologies obtaining therapeutic, prophylactic and diagnostic drugs for healthcare and veterinary needs, developing new instrumental methods studying biological and bioaerosol systems. Research areas include:

• theoretical and experimental study of the spread of aerosol pollution and bioaerosols in the atmosphere, their impact on public health and the development of preventive measures for areas with unfavorable environmental situation;
• development of new methods and means of specific prevention;
• development of new types of samplers and equipment for identifying the biogenic component in aerosol impurities;
• development of new methodological approaches for express diagnostics of the sensitivity of microorganisms to allergens and drugs.

WHO Collaborating Center for the Diagnosis of Orthopoxvirus Infections and Museum of Smallpox Virus Strains and DNA

(supervisor - Academician of the Russian Academy of Sciences, Doctor of Biological Sciences, Professor L.S. Sandakhchiev)

Laboratory Animal Nursery

(director - V.N. Bondarenko)

Subsidiaries:

Subsidiary state unitary experimental production enterprise "Vector-BiAlgam"

(director - L.G. Nikulin)

"Vector-BiAlgam" is one of the leading enterprises in the field of development and production of immunobiological products and bifid-containing drugs and products.

• More than 20 dairy industry enterprises operate using Vector-BiAlgam technologies, including Siberian Milk LLC (Novosibirsk), Siberian Dairy Company LLC (Kemerovo);
• A new promising strain of bifidobacteria has been patented in Russia and confirmed by a Eurasian patent;
• By orders of the Ministry of Health of the Russian Federation, the Ministry of Justice of the Russian Federation and the Ministry of Internal Affairs of the Russian Federation, supplies of hepatitis A vaccine are carried out;
• As part of the new project, a mini-factory is being built to produce bifid-containing baby food;
• A divaccine for hepatitis A and B has been developed and is undergoing clinical trials.

Subsidiary state unitary production enterprise "Vector-Pharm"

(Director - Candidate of Physical and Mathematical Sciences S.N. Targonsky)

Main activities:

• Production of therapeutic and diagnostic drugs developed at the Center.
• Launching the production of healthcare products using technologies developed by third parties.
• Production of finished dosage forms in cooperation with foreign firms and companies.
• Storage and sales of products produced by the Center.

Subsidiary state unitary experimental production agricultural enterprise "Vector-OPSP"

(director - D.N. Loktionov)

Main activities:

• Development of technology for growing medicinal herbs.
• Breeding deer to produce antlers.
• Creation of an experimental base for obtaining cattle whey.
• Preparation of feed for keeping laboratory animals.

Branches operating on the basis of regulations

Research Design and Technology Institute of Biologically Active Substances (NIKTI BAV)

(Director - Doctor of Biological Sciences V.I. Masycheva)

Main activities:

• Creation of methods for obtaining products of modern biotechnology: recombinant cytokines and mutant versions of recombinant proteins, nucleic acids.
• Conducting preclinical tests of drugs for medical and veterinary purposes.
• Development of technologies for obtaining substances and dosage forms for the prevention and treatment of immunodeficiency, cancer and infectious diseases of humans and animals.
• Creation of molecular constructs for targeted delivery of protein and genetic material.
• Development of diagnostic test systems for identifying infectious diseases.

(FBU SSC VB “Vector”)

brief information

One of the largest virological and biotechnological centers in Russia. Fundamental research work is focused on obtaining new scientific knowledge in the field of molecular epidemiology, molecular biology, genetic and cellular engineering, biotechnology, nanobiotechnology, ecology and biological safety. Applied research is aimed at developing effective means and methods for the prevention, treatment and diagnosis of infectious diseases. Since 1997, the WHO Collaborating Center for the Diagnosis of Orthopoxvirus Infections and a museum of variola virus strains and DNA have been operating on the basis of the State Scientific Center for Virology and Biochemistry “Vector”. Since 2009, the WHO reference laboratory for diagnosing H5 influenza, the only one in Russia and one of 13 in the world, has been operating on the basis of the State Scientific Center for Virology and Biotechnology “Vector”.

The mission of the Center is scientific and practical support for countering global biological threats.

Founded (created)

The center was founded in 1974. In 1994, by Decree of the Government of the Russian Federation dated March 29, 1994 No. 247, it was given the status of the State Scientific Center of the Russian Federation, confirmed to date by the relevant regulations Government of the Russian Federation (1997, 2000, 2002, 2004, 2007, 2009, 2011, 2013).

Work on priority areas and critical technologies for the development of science, technology and engineering

Work is carried out in priority areas of science, technology and engineering of the Russian Federation: “Security and countering terrorism”, “Science and life” and in critical technologies: “Biocatalytic, biosynthetic and biosensor technologies”, “Biomedical and veterinary technologies”, “Genomic, proteomic and postgenomic technologies”, “Cell technologies”, “Nano-, bio-, information, cognitive technologies”, “Bioengineering technologies”.

Participation in the implementation of technology platforms

FBUN SSC VB "Vector" is members Technology platform“Medicine of the Future” and the Technological Platform “Environmental Development Technologies”.

Innovative projects

Multiplex test systems for identifying infections transmitted through tick and mosquito bites, multiplex test systems for identifying more than 10 intestinal infections, cultural, recombinant and DNA vaccines against socially significant and especially dangerous viral diseases, including variola virus, polyepitope vaccines against HIV/AIDS and other infectious diseases of humans and animals, new methods of delivering vaccines and drugs (tablets, microencapsulated, nanomicroencapsulated), antiviral and antitumor drugs, new methods for the differential diagnosis of somatic diseases using dielectrophoresis, mathematical models spread of epidemics of infectious diseases.

Research experimental base

A unique scientific and experimental base for conducting research with the most dangerous viruses to humans, including those for which there is no treatment or specific prevention, in complete safety for working personnel and the environment. Modern equipment for molecular biological, diagnostic, biotechnological, aerosol research. Availability of a site for the production of vaccine preparations, a site for the production of culture media, measles vaccine in accordance with GMP requirements, as well as pilot sites for the production of pilot batches of vaccine and medicines being developed.

Patents, certificates

178 valid patents of the Russian Federation, 4 utility models, 20 certificates.

Number of personnel engaged in research and development

Availability of Agreements with higher authorities educational institutions

Novosibirsk Medical University;

Novosibirsk State University;

Altai State University;

Novosibirsk State Agrarian University;

National Research Tomsk Polytechnic University.

Basic departments, scientific schools

The Center has four leading scientific and pedagogical schools: microbiology, immunology and virology, genetic engineering, biotechnology. There is an agreement with Altai State University on the creation of a basic department of “biopharmaceuticals based on recombinant technologies.”

Main partners

Carries out scientific cooperation with institutions of the Russian Academy of Sciences, SB RAS, RAMS, SB RAMS, SB RAAS, research institutions of Rospotrebnadzor, with the State Scientific Center of the Russian Federation, higher educational institutions and pharmaceutical enterprises.

International scientific and technical cooperation

Cooperation:

With WHO influenza as a member of the WHO Global Influenza Surveillance and Response System;

With WHO as experts on the WHO Advisory Committee on the Study of Variola Virus;

With the Centers for Disease Control and Prevention (CDC, Atlanta, USA); - with the WHO Reference Laboratory for influenza H5 subtype (Hong Kong, China);

With the WHO Collaborating Center for the Study of the Ecology of Influenza in Animals and Birds (Memphis, USA);

WHO Collaborating Center for Reference Diagnostics and Research on Influenza (London, UK);

With the Northwestern Institute of Biology Plateau of the Chinese Academy of Sciences, with the Beijing Institute of Biological Sciences of the Chinese Academy of Sciences, with the Institute of Immunology of the Academy of Sciences of the Republic of Uzbekistan, with national centers influenza of the CIS countries (Kazakhstan, Kyrgyzstan, Azerbaijan, Belarus, Uzbekistan, Tajikistan).

Since August 2014, in the Republic of Guinea, as part of the ongoing work to assist West African countries in the fight against Ebola virus disease (EVD), a Russian laboratory began operating on the basis of a mobile complex of a specialized anti-epidemic team of Rospotrebnadzor.

Federal state-financed organization science “State Scientific Center for Virology and Biotechnology “Vector” of the Federal Service for Surveillance in the Sphere of Consumer Rights Protection and Human Welfare is one of the largest scientific virological and biotechnological centers in Russia.

The mission of the Center is scientific and practical support for countering global infectious threats.

The Center was organized in 1974. It includes a branch - the Institute of Medical Biotechnology, located in Berdsk, Novosibirsk Region.

Today, the fundamental research work of the State Research Center for Virology and Biotechnology “Vector” is focused on obtaining new scientific knowledge in the field of epidemiology, molecular biology, virology, bacteriology, genetic engineering, biotechnology, ecology and biological safety. The Center's applied research is aimed at developing effective means and methods for the prevention, treatment and diagnosis of infectious diseases, creating and improving biotechnologies for the production of means to counteract infectious pathogens.

The main tasks facing the Center:

• fundamental research into pathogens of particularly dangerous and socially significant viral infections, their genetic variability and diversity, the pathogenesis of viral infections;
• ensuring constant readiness to diagnose particularly dangerous infectious agents;
• development and implementation of diagnostic, therapeutic and preventive means into healthcare practice;
• postgraduate training of specialists, as well as training of highly qualified scientific personnel in the field of virology, molecular biology and biotechnology through postgraduate studies and competition.

SSC VB “Vector” was one of the first in Russia to develop and produce test systems for diagnosing HIV infection and hepatitis B; was the first in Russia to organize the production of genetically engineered human interferon-a-2; developed and introduced into production the immunostimulating drug Ridostin, which has antiviral activity, including against influenza; Together with the Institute of Poliomyelitis and Viral Encephalitis of the Russian Academy of Medical Sciences, he developed the only domestic vaccine against viral hepatitis A and introduced it into production.

In the main areas of scientific activity, SSC VB “Vector” actively cooperates with various institutions of the Russian Academy of Sciences, the Russian Academy of Medical Sciences, the Russian Academy of Agricultural Sciences, Rospotrebnadzor, the Ministry of Health and Social Development and the Ministry of Emergency Situations of Russia.

SSC VB “Vector” carries out international partnerships in the field of molecular epidemiology, virology, and biosafety with leading foreign scientific centers. Cooperation with CIS countries in the field of monitoring of avian influenza is expanding. In 2006-2007 Rospotrebnadzor concluded agreements on cooperation in the field of diagnosis and monitoring of influenza viruses with the Ministries of Health of Ukraine, Kazakhstan, Belarus, Uzbekistan and Azerbaijan. It is planned to conclude similar agreements with all CIS countries by the end of 2007. In addition, cooperation agreements have been concluded between the national influenza centers of Russia, Kazakhstan and Ukraine. On their basis, joint expeditions and studies of isolated influenza virus strains, exchange of information, strains, and specialists are already taking place and will be constantly carried out. It is planned to organize trainings both at the State Research Center for Virology and Biotechnology “Vector” and the Central Research Institute of Epidemiology of Rospotrebnadzor, and in the countries participating in agreements and treaties.

Since 1997, one of the two WHO Collaborating Centers in the world for the diagnosis of orthopoxvirus infections and a museum of smallpox virus strains and DNA has been operating on the basis of the State Scientific Center for Virology and Biochemistry “Vector”.

For more than seven years, the Ethical and Bioethical Committees have been working at the State Scientific Center for Virology and Biotechnology “Vector”, main task which is the examination of international and Russian biomedical scientific research in order to protect the rights, interests, dignity and safety of people who voluntarily participate in these studies.

Since the beginning of 2005, the Center, as part of the Department of Zoonotic Infections and Influenza, has organized a laboratory for working with highly pathogenic strains of influenza virus, including avian influenza viruses. In accordance with the Order of Rospotrebnadzor dated May 10, 2007 No. 144, an industry-wide scientific and methodological center for reference diagnostics and the study of highly pathogenic strains of the influenza virus was created on the basis of the State Research Center for Virology and Biotechnology “Vector”. A WHO reference laboratory for diagnosing H5N1 influenza has been created and is successfully operating on the basis of the Federal Budgetary Institution of Scientific Institutions State Scientific Fund "Vector". For the second year, work has been underway to secure the status of a WHO collaborating center for influenza for the Center (a candidate WHO CC since 2009)

Within the structure of the State Research Center for Virology and Biochemistry "Vector" there are expedition groups for collecting samples from outbreaks of infectious diseases, which successfully work in areas of outbreaks of avian influenza and other zoonotic infections. Highly qualified Vector specialists are hired to promptly examine samples and confirm diagnoses during outbreaks of diseases of unknown etiology in Russia.

The scientific potential of the State Scientific Center for Virology and Biotechnology “Vector” consists of highly qualified specialists in the field of virology, molecular biology, genetic and cellular engineering, epidemiology and biotechnology. Headcount center - 1614 people, of which 139 are doctors and candidates of science.

The unique asset of the Center is its highly qualified scientific and engineering personnel and laboratory and experimental facilities, which allow conducting research with viruses pathogenic to humans and animals in conditions of complete safety for personnel and the environment.

In-depth research by scientists and specialists of the Center has a significant impact on scientific policy in Russia in the field of control over infectious diseases. Research in the field of molecular epidemiology of viral infections, the relationship between the structure and function of viral genomes, the mechanisms of the pathogenesis of infectious diseases, including the study of the relationship between the genetic characteristics of the host and the viral agent with the characteristics of the infectious process, are important strategic directions that will undoubtedly provide concrete practical results in the future in terms of operational forecasting of outbreaks of “emerging” and “re-emerging” infections, as well as the creation of fundamentally new preventive and therapeutic drugs for public health.